Artikel
Functional characterization of the relative ellipsoid zone reflectivity in AMD
Suche in Medline nach
Autoren
-
Yannick N. Liermann
- Bonn/D
-
C. Behning
- Bonn/D
-
M. Saßmannshausen
- Bonn/D
-
L. Weinhold
- Bonn/D
-
B. Isselmann
- Bonn/D
-
M. Schmid
- Bonn/D
-
R.P. Finger
- Bonn/D
-
S. Schmitz-Valckenberg
- Bonn/D; Salt Lake City/USA
-
F.G. Holz
- Bonn/D
-
M. Pfau
- Bonn/D; Basel/CH
-
C.D. Luu
- Melbourne/AUS
-
S. Thiele
- Bonn/D
| Veröffentlicht: | 7. September 2023 |
|---|
Gliederung
Text
Background: First investigations suggest that the relative ellipsoid zone reflectivity (rEZR) on spectral-domain optical coherence tomography (SD-OCT) is an innovative surrogate for outer retinal integrity.
Purpose: To better understand the rEZR’s potential value as a novel biomarker, this study evaluates the association between the rEZR and retinal function as assessed by fundus-controlled microperimetry (FCP).
Methods: Study participants of the MACUSTAR study with age-related macular degeneration (AMD) and controls underwent SD-OCT Spectralis imaging (241 B-scans, field size 30°x25°). Mesopic and scotopic FCP with a 33-stimulus point grid was performed using the S-MAIA microperimeter (Centervue, Padova, Italy). The rEZR was determined in OCT raw images as the mean per volume scan (global) and spatially-resolved at each aligned FCP test point. Topographical information of the presence of reticular pseudodrusen (RPD) was determined by manual annotation of the RPD area in en-face infrared imaging. Linear mixed-effects models were applied to determine the association between the rEZR [arbitrary units, AU] and retinal sensitivity [dB], with co-variates adjusting for AMD status, age and eccentricity as well as the presence of RPD within the iAMD subgroup.
Results: A total of 281 eyes of 281 patients of (mean±SD) XY±XY years were included. In the global analysis, higher mesopic and scotopic average thresholds (AT) were significantly associated with a higher rEZR (coefficient estimate [95%-confidence interval (min-max)]) of 0.04 (0.01–0.07) AU (p=0.006) and 0.07 (0.04–0.10) AU (p<0.001), respectively. Further, the mesopic (-3.0 [-4.85–1.16] AU) and scotopic (-4.42 [-6.22–2.61] AU) ATs were shown to be more reduced in iAMD eyes with RPD (both: p≤0.002). Topographically, the rEZR was significantly associated with the stimulus threshold (ST) in mesopic (0.16 [0.07–0.26] AU) and scotopic (0.14 [0.03–0.24] AU) FCP (both: p<0.01). The rEZR was more decreased in RPD areas both when considering mesopic (-2.99 [-5.84 – -0.13] AU; p=0.040) and scotopic (-5.56 [-8.55 – -2.56] AU; p<0.001) FCP testing.
Conclusions: The rEZR showed an association with retinal sensitivity both globally and spatially-resolved, highlighting a potential structural-functional relation. Further, the presence of RPD, a known high-risk factor for AMD progression, significantly affects this association.
