Artikel
Predictive value of early postoperative MELD scores on patient and graft survival after liver transplantation
Suche in Medline nach
Autoren
Veröffentlicht: | 24. April 2015 |
---|
Gliederung
Text
Introduction: Early allograft dysfunction after liver transplantation is not well defined. The aim of this study was to evaluate predictive value of early postoperative MELD scores on 3- and 12-months survival.
Material and methods: In this single center retrospective study, 362 consecutive patients after liver transplantation were included. MELD scores at 7, 14, and 21 postoperative days (POD) were calculated from primary lab values.
Results: About 90% of patients survived 3 months and 85% one year after transplantation. The graft survival rate was 90% after 3 months and 86% after one year. The MELD scores were on POD-7 21±7 and 18±8 (dead vs. alive patients, respectively), on POD-14: 20±8 vs. 15±7, at POD-21: 19±8 vs. 15±7 As shown by ROC analysis, the best cutoff of MELD score predicting the one-year patient survival was on POD-14 (17 for one-year survival and 19 for 3 months-survival, p<0.001). For the graft survival, the optimal cutoff was on POD-7: 29 for the one year and 27 for 3-moths-survival (p<0.001).
Conclusion: In conclusion, MELD scores early after liver transplantation are predictive for 3 and 12 months outcome. The postoperative MELD score on POD-14 is a good predictor for the patient survival and on POD-7 for the graft survival after liver transplantation.