Artikel
No association between serum insulin-like growth factor-1 and left ventricular hypertrophy
Suche in Medline nach
Autoren
Veröffentlicht: | 6. September 2007 |
---|
Gliederung
Text
Background: Left ventricular hypertrophy (LVH) is a major cardiac sequel of hypertension and represents a powerful predictor of cardiovascular morbidity and mortality. Serum insulin-like growth factor-1 (IGF-1) mediates multiple physiological as well as pathophysiological responses in the cardiovascular system. Previous studies reported of a possible association between serum IGF-1 and LVH. The objectives of the present study were to investigate the association between serum IGF-1 levels and left ventricular mass (LVM) as well as LVH in a population-based study.
Methods: From the Study of Health in Pomerania a total number of 1,865 subjects were selected. Echocardiography was performed and LVM was calculated. LVH was defined as a LVM ≥294g for men and ≥198g for women. Serum IGF-1 concentration was determined by chemiluminescence immunoassays. Linear and logistic regressions were performed.
Results: LVH was present in 25.2% of the women and 12.1% of the men. In females and males, subjects with LVH were older, had a higher body mass index and waist-to-hip ratio. Hypertension and diabetes were more common in women and men with LVH. Women with LVH had significantly lower levels of serum IGF-1 compared to women without LVH. Multivariable analyses yielded no associations between serum IGF-1 levels and LVM as well as LVH neither in women nor in men.
Conclusions: In conclusion, in contrast to previous studies, our data showed no significant associations between serum IGF-1 levels and LVM as well as LVH.
References
- 1.
- Kannel W, Cobb J. Left ventricular hypertrophy and mortality - results from the Framingham Study. Cardiology 1992; 81:291-298.
- 2.
- Kuch B, Schunkert H, Muscholl M, Döring A, von Scheidt W, Hense H-W. Distribution, determinants and reference values of left ventricular parameters in the general population-results of the MONICA/KORA-echocardiography studies. Gesundheitswesen 2005; 67:68-73.
- 3.
- Ren J, Samson WK, Sowers JR. Insulin-like growth factor I as a cardiac hormone: physiological implications in heart disease. J Mol Cell Cardiol 1993; 31:2049-2061.
- 4.
- Delafontaine P. Insulin-like growth factor I and its binding proteins in the cardiovascular system. Cardiovasc Res. 1995; 30:825-834.
- 5.
- Diez J, Laviades C, Martinez E, Gil MJ, Monreal I, Fernandez J, Prieto J. Insulin-like growth factor binding proteins in arterial hypertension: relationship to left ventricular hypertrophy. J Hypertens. 1995; 13:349-55.
- 6.
- Sesti G, Sciacqua A, Scozzafava A, Vatrano M, Angotti E, Ruberto C, Santillo E, Parlato G, Perticone F. Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients. J Hypertens. 2007; 25:471-477.