Artikel
Genetic variants in the USF1 gene are not associated with MetS, T2DM, and related parameters in Caucasians (KORA study)
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Veröffentlicht: | 6. September 2007 |
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Background: Upstream stimulatory factor 1 (USF1) regulates numerous genes of glucose and lipid metabolism and genetic variants in the USF1 gene show association with familial combined hyperlipidemia (FCHL), which shows phenotypic overlap with the metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM). The aim of our study was to approve the hypothesis that polymorphisms in the USF1 gene are associated with MetS and related metabolic traits.
Materials and methods: We genotyped eight single nucleotide polymorphisms (SNPs) in the USF1 gene in 1,653 individuals of the population-based German Caucasian KORA study in the age range between 55 and 74 years. Because of high correlation only six polymorphisms were statistically analyzed. The association with T2DM and the MetS was analyzed by logistic regression in 1,462 subjects and the quantitative parameters were analyzed in 1,231 fasting non diabetic subjects by linear regression respectively by Kruskal-Wallis test.
Results: None of the analyzed genetic variants (rs2774279, rs10908821, rs1556259, rs2516839, rs3737787, rs2774276) show significant association with T2DM and MetS. The results for the metabolic traits like triglyzerides, total cholesterol, HDL (high density lipoprotein) cholesterol, LDL (low density lipoprotein) cholesterol, percent body fat, waist to hip ratio, ureic acid, fasting glucose, 2 hour plasma glucose, fasting insulin, blood pressure (systolic and diastolic) give also no evidence for any association with USF1.
Conclusion: In our large population based study no association between single genetic variants in the USF1 gene and T2DM, MetS and related metabolic parameters was found. We conclude that the single genetic variants in USF1 have no major effect on lipid and glucose parameters in German Caucasians.